Evaluation of rapid polymyxin Nordmann Poirel test for detection of polymyxin resistance in clinical isolates of Enterobacteriaceae.

Muhammad Shoaib, Ashfaq Hussain, Luqman Satti, Wajid Hussain, Gohar Zaman, Faisal Hanif

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2020 Nov

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Polymyxins play a significant role against carbapenem-resistant Enterobacteriaceae (CRE). A total of 121 clinical samples yielded growth of CRE that were included in the study. Rapid Polymyxin NP test was performed on all the isolates as described by Nordmann P et al. and results were compared with broth microdilution method. Majority of the isolates were Klebsiella pneumoniae (70.2%) followed by Escherichia coli (17.4%). A total of 71 isolates were found resistant and 50 as susceptible by broth microdilution. Sensitivity and specificity of rapid polymyxin NP test were found to be 97.2% and 100%, respectively. Our study concluded that rapid polymyxin NP test is reliable and can be used as an alternative to broth microdilution in resource limited settings.

Citation

Muhammad Shoaib, Ashfaq Hussain, Luqman Satti, Wajid Hussain, Gohar Zaman, Faisal Hanif. Evaluation of rapid polymyxin Nordmann Poirel test for detection of polymyxin resistance in clinical isolates of Enterobacteriaceae. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2020 Nov;39(11):2195-2198