Intra-abdominal hypertension as a trigger of "gut failure" in SARS-CoV-2 infection: Effect of open abdomen (OA) and negative pressure therapy (NPT) on respiratory and gastrointestinal (GI) function.

Marta Di Grezia, Pietro Fransvea, Francesco Santullo, Flavio Tirelli, Valeria Fico, Paolo Mirco, Valerio Cozza, Antonio La Greca, Gabriele Sganga

Medical hypotheses 2020 Nov

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COVID-19 gastrointestinal manifestations could be attributed to SARS-CoV-2-induced small vessel thrombosis. OA with NPT treatment may have a role in optimization of bowel microcirculation and in the reduction of the endothelial and the systemic cytokine-related damage, improving also respiratory function. Copyright © 2020 Elsevier Ltd. All rights reserved.

Citation

Marta Di Grezia, Pietro Fransvea, Francesco Santullo, Flavio Tirelli, Valeria Fico, Paolo Mirco, Valerio Cozza, Antonio La Greca, Gabriele Sganga. Intra-abdominal hypertension as a trigger of "gut failure" in SARS-CoV-2 infection: Effect of open abdomen (OA) and negative pressure therapy (NPT) on respiratory and gastrointestinal (GI) function. Medical hypotheses. 2020 Nov;144:109954