Stereospecific synthesis of phosphatidylglycerol using a cyanoethyl phosphoramidite precursor.

Zachary J Struzik, Ashley N Weerts, Judith Storch, David H Thompson

Chemistry and physics of lipids 2020 Sep

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Phosphatidylglycerols (PG) are a family of naturally occurring phospholipids that are responsible for critical operations within cells. PG are characterized by an (R) configuration in the diacyl glycerol backbone and an (S) configuration in the phosphoglycerol head group. Herein, we report a synthetic route to provide control over the PG stereocenters as well as control of the acyl chain identity. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Zachary J Struzik, Ashley N Weerts, Judith Storch, David H Thompson. Stereospecific synthesis of phosphatidylglycerol using a cyanoethyl phosphoramidite precursor. Chemistry and physics of lipids. 2020 Sep;231:104933