Study of tocopherol content and its potential antioxidant activity in commercial lipid emulsions for parenteral nutrition.

A Novak, M Gutiérrez-Zamora, P Pérez-Lozano, J M Suñé-Negre, J M Llop, J R Ticó, M Miñarro, E García-Montoya, A Van Schepdael

Die Pharmazie 2020 Jun 01

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The objective of this study was to determine the content and evaluate the potential antioxidant effect of tocopherols in commercially available lipid emulsions, using a simple validated method adequate for further routine use. During the study, variability between manufacturers as well as between three non-consecutive batches of the same emulsion was observed. Furthermore, addition of α-tocopherol to lipid emulsions as excipient yields more stable emulsions and potentially a beneficial clinical effect. It was concluded that the variation of the tocopherol content between batches implies the importance of control and specification of tocopherol content by the manufacturers.

Citation

A Novak, M Gutiérrez-Zamora, P Pérez-Lozano, J M Suñé-Negre, J M Llop, J R Ticó, M Miñarro, E García-Montoya, A Van Schepdael. Study of tocopherol content and its potential antioxidant activity in commercial lipid emulsions for parenteral nutrition. Die Pharmazie. 2020 Jun 01;75(6):240-241