MiR-520c-3p alleviates LPS-induced A549 cell and mice lung injury via targeting NLRC5.

Na-Na Li, Tao Cao, Fei Yu, Lian Luo, Ping Liu

Die Pharmazie 2020 Jun 01

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MicroRNAs (miRNAs) play important roles in the progression of acute lung injury (ALI). So far, little is known about the role of miR-520c-3p in ALI. In this study, the mechanism of the occurrence and development of ALI was explored. We firstly found that miR-520c-3p could inhibit the expression of NLRC5. A549 cells were treated with lipopolysaccharide (LPS) in vitro to simulate ALI cells and inducing ALI model mice. Moreover, miR-520c-3p overexpression enhanced the viability of damaged cells, inhibited LPS-induced apoptosis, and decreased LPS-induced IL-1β, IL-6 and TNF-α. In addition, the NLRC5 was a direct target of miR-520c-3p. And NLRC5 partially aggravated inflammation injury. In conclusion, miR-520c-3p alleviates LPS-induced inflammatory injury via regulating NLRC5.

Citation

Na-Na Li, Tao Cao, Fei Yu, Lian Luo, Ping Liu. MiR-520c-3p alleviates LPS-induced A549 cell and mice lung injury via targeting NLRC5. Die Pharmazie. 2020 Jun 01;75(6):275-278