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    The cytokines of the interleukin (IL) -1 family act in the initiation of an effective immune response in Leishmania infection, represented mainly by the T helper 1 (Th1) profile, in addition to being associated with disease exacerbation and controversial contributions in the Th2 responses. The family also includes members who self-regulate inflammation, such as antagonists and anti-inflammatory cytokines, most of which have not yet been studied in Cutaneous Leishmaniasis (CL) in humans. Here we summarize findings about what is known so far about the role of these cytokines in mice, the main study model, and in humans. We reinforce the importance of studies of these cytokines as new targets in the context of CL. Copyright © 2020 Elsevier Ltd. All rights reserved.


    Ester Alves da Silva Amorim, Áquila Alcântara de França, Valéria Rêgo Alves Pereira, Maria Carolina Accioly Brelaz-de-Castro. IL-1 family and Cutaneous Leishmaniasis: A poorly understood relationship. Cytokine & growth factor reviews. 2021 Feb;57:85-92

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    PMID: 32540132

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