Unique cellular interaction of macrophage-targeted liposomes potentiates anti-inflammatory activity.

Riki Toita, Eiko Shimizu, Jeong-Hun Kang

Chemical communications (Cambridge, England) 2020 Jul 28

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Nanomedicines that suppress macrophage-mediated chronic inflammation are important therapeutics for many inflammatory diseases. The small-sized (<100 nm) apoptotic-cell-mimetic macrophage-targeted liposomes served as a long-lasting immunosuppressive agent through preferential association with CD300a receptor, unlike larger liposomes, enabling the amelioration of hepatic inflammation in mice.

Citation

Riki Toita, Eiko Shimizu, Jeong-Hun Kang. Unique cellular interaction of macrophage-targeted liposomes potentiates anti-inflammatory activity. Chemical communications (Cambridge, England). 2020 Jul 28;56(59):8253-8256