Analysis of Taste Sensitivities in App Knock-In Mouse Model of Alzheimer's Disease.

Some studies have reported a decline in taste sensitivities in patients with Alzheimer's disease. However, the detail remains unknown. We investigated the effect of cognitive impairment on taste sensitivity using an App knock-in mouse model of Alzheimer's disease. Behavioral assays, a brief access test, and a 48 h two-bottle preference test, to assess taste sensitivities were started from 12 months of age in mice that were confirmed to have impaired cognition. In the assays, there was no significant difference in taste sensitivities between wild type and App knock-in mice. Additionally, no apparent difference was observed in the expression of taste markers in their taste bud cells. We concluded that cognitive impairment might not greatly affect taste sensitivity.

Citation

Masataka Narukawa, Suzuka Takahashi, Takashi Saito, Takaomi C Saido, Takumi Misaka. Analysis of Taste Sensitivities in App Knock-In Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2020;76(3):997-1004

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PMID: 32568206

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