The Brighton Collaboration standardized template for collection of key information for benefit-risk assessment of nucleic acid (RNA and DNA) vaccines.

Vaccine 2020 Jul 22

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Nucleic acid (DNA and RNA) vaccines are among the most advanced vaccines for COVID-19 under development. The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG) has prepared a standardized template to describe the key considerations for the benefit-risk assessment of nucleic acid vaccines. This will facilitate the assessment by key stakeholders of potential safety issues and understanding of overall benefit-risk. The structured assessment provided by the template can also help improve communication and public acceptance of licensed nucleic acid vaccines. Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

Citation

Denny Kim, James S Robertson, Jean-Louis Excler, Richard C Condit, Patricia E Fast, Marc Gurwith, George Pavlakis, Thomas P Monath, Jonathan Smith, David Wood, Emily R Smith, Robert T Chen, Sonali Kochhar, Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG). The Brighton Collaboration standardized template for collection of key information for benefit-risk assessment of nucleic acid (RNA and DNA) vaccines. Vaccine. 2020 Jul 22;38(34):5556-5561