Neocurromycin A, a new GRP78 downregulator from Streptomyces sp. RAI364.

Yoichi Hayakawa, Ryodai Yaguchi, Minami Akimoto, Shoko Kimata, Kazuo Shin-Ya

The Journal of antibiotics 2020 Nov

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A new curromycin-related compound, neocurromycin A (2), was isolated from the fermented broth of Streptomyces sp. RAI364. The molecular formula of 2 was established as C35H44N4O7 by ESI-MS and the structure was elucidated by NMR spectroscopic analyses. Neocurromycin A showed selective cytotoxicity against MKN45 human gastric cancer cells in a nutrient-deprived medium with an IC50 of 380 nM and inhibited the expression of the molecular chaperone GRP78 in HT1080 G-L cells in the presence of 10 mM of 2-deoxyglucose with an IC50 of 1.7 µM.

Citation

Yoichi Hayakawa, Ryodai Yaguchi, Minami Akimoto, Shoko Kimata, Kazuo Shin-Ya. Neocurromycin A, a new GRP78 downregulator from Streptomyces sp. RAI364. The Journal of antibiotics. 2020 Nov;73(11):790-793