Emerging of lysine demethylases (KDMs): From pathophysiological insights to novel therapeutic opportunities.

Sarder Arifuzzaman, Mst Reshma Khatun, Rabeya Khatun

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep

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In recent years, there have been remarkable scientific advancements in the understanding of lysine demethylases (KDMs) because of their demethylation of diverse substrates, including nucleic acids and proteins. Novel structural architectures, physiological roles in the gene expression regulation, and ability to modify protein functions made KDMs the topic of interest in biomedical research. These structural diversities allow them to exert their function either alone or in complex with numerous other bio-macromolecules. Impressive number of studies have demonstrated that KDMs are localized dynamically across the cellular and tissue microenvironment. Their dysregulation is often associated with human diseases, such as cancer, immune disorders, neurological disorders, and developmental abnormalities. Advancements in the knowledge of the underlying biochemistry and disease associations have led to the development of a series of modulators and technical compounds. Given the distinct biophysical and biochemical properties of KDMs, in this review we have focused on advances related to the structure, function, disease association, and therapeutic targeting of KDMs highlighting improvements in both the specificity and efficacy of KDM modulation. Copyright © 2020 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.

Citation

Sarder Arifuzzaman, Mst Reshma Khatun, Rabeya Khatun. Emerging of lysine demethylases (KDMs): From pathophysiological insights to novel therapeutic opportunities. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Sep;129:110392