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To investigate the function of chromobox 2 (CBX2) in oesophageal squamous cell carcinoma (OSCC). We used real-time quantitative reverse transcription PCR (qRT-PCR) and immunohistochemistry to determine CBX2 expression levels in 13 human OSCC cell lines and clinical specimens of two independent cohorts of patients with OSCC. PCR array analysis revealed that CBX2 was co-ordinately expressed with WNT5B in OSCC cell lines. RT-qPCR analysis of clinical samples revealed a high tumour-specific CBX2 expression compared with normal oesophageal tissues. High CBX2 expression was significantly associated with shorter disease-specific survival, hematogenous recurrence, and overall recurrence. Analysis of tissue microarrays of one cohort revealed that patients with higher CBX2 levels tended to have a shorter disease-specific survival. CBX2 overexpression in OSCC tissues may serve as a novel biomarker for predicting survival and hematogenous recurrence. Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Citation

Sei Ueda, Mitsuro Kanda, Yusuke Sato, Hayato Baba, Shunsuke Nakamura, Koichi Sawaki, Dai Shimizu, Satoru Motoyama, Tsutomu Fujii, Yasuhiro Kodera, Shuji Nomoto. Chromobox 2 Expression Predicts Prognosis After Curative Resection of Oesophageal Squamous Cell Carcinoma. Cancer genomics & proteomics. 2020 Jul-Aug;17(4):391-400

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PMID: 32576584

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