HaDeX: an R package and web-server for analysis of data from hydrogen-deuterium exchange mass spectrometry experiments.

Weronika Puchała, Michał Burdukiewicz, Michał Kistowski, Katarzyna A Dąbrowska, Aleksandra E Badaczewska-Dawid, Dominik Cysewski, Michał Dadlez

Bioinformatics (Oxford, England) 2020 Aug 15

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Hydrogen-deuterium mass spectrometry (HDX-MS) is a rapidly developing technique for monitoring dynamics and interactions of proteins. The development of new devices has to be followed with new software suites addressing emerging standards in data analysis. We propose HaDeX, a novel tool for processing, analysis and visualization of HDX-MS experiments. HaDeX supports a reproducible analytical process, including data exploration, quality control and generation of publication-quality figures. HaDeX is available primarily as a web-server (http://mslab-ibb.pl/shiny/HaDeX/), but its all functionalities are also accessible as the R package (https://CRAN.R-project.org/package=HaDeX) and standalone software (https://sourceforge.net/projects/HaDeX/). Supplementary data are available at Bioinformatics online. © The Author(s) 2020. Published by Oxford University Press.

Citation

Weronika Puchała, Michał Burdukiewicz, Michał Kistowski, Katarzyna A Dąbrowska, Aleksandra E Badaczewska-Dawid, Dominik Cysewski, Michał Dadlez. HaDeX: an R package and web-server for analysis of data from hydrogen-deuterium exchange mass spectrometry experiments. Bioinformatics (Oxford, England). 2020 Aug 15;36(16):4516-4518