Correlation Engine 2.0
Clear Search sequence regions

  • brain (1)
  • CTBS (14)
  • dilates (1)
  • mice (3)
  • sunitinib (3)
  • theta rhythm (1)
  • treatment sham (1)
  • VEGF- C (7)
  • VEGFR (1)
  • VEGFR3 (1)
  • vessels (9)
  • Sizes of these terms reflect their relevance to your search.

    Lymphatic vessels (LVs) of meninges and lymphatic drainage in the brain have been investigated previously. Here, we examined the role of continuous theta burst stimulation (CTBS) in the modulation of meningeal LVs. To explore the effects of CTBS on meningeal LVs, the diameters of LVs were measured between a real CTBS group and sham CTBS group of wild-type male mice. Vascular endothelial growth factor-C (VEGF-C) expression was subsequently calculated in both groups to account for lymphatic changes after CTBS. Sunitinib was administered by 3-day oral gavage to inhibit the VEGF receptor (VEGFR), and the effects of CTBS were further examined in the following groups: vehicle with real CTBS, vehicle with sham CTBS, sunitinib treatment with real CTBS, and sunitinib treatment with sham CTBS. The lymphatic vessels were augmented, and the level of VEGF-C in meninges increased after CTBS. CTBS dilated meningeal lymphatic vessels were impaired after the VEGF-C/VEGFR3 pathway was blocked. CTBS can dilate meningeal lymphatic vessels by up-regulating VEGF-C in meninges. Copyright © 2020. Published by Elsevier B.V.


    Meng-Ni Li, Ying-Hua Jing, Cheng Wu, Xue Li, Feng-Yin Liang, Ge Li, Pei Dai, Hui-Xian Yu, Zhong Pei, Guang-Qing Xu, Yue Lan. Continuous theta burst stimulation dilates meningeal lymphatic vessels by up-regulating VEGF-C in meninges. Neuroscience letters. 2020 Sep 14;735:135197

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 32590044

    View Full Text