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The formation of a mature, multilayered myelin sheath requires the compaction of lipid bilayers, but the molecular mechanism by which these bilayers condense is an open question. In this issue, Ruskamo et al. find that peripheral myelin protein P2 forms an ordered three-dimensional lattice within model membranes using Escherichia coli polar lipid liposomes. These data will help to understand the assembly, function, and structure of the myelin sheath. © 2020 Tsuge.


Hideaki Tsuge. A myelin sheath protein forming its lattice. The Journal of biological chemistry. 2020 Jun 26;295(26):8706-8707

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PMID: 32591442

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