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    We sought effective (directional) connectivity parameters associated with response to citalopram in cocaine use disorder (CUD) by conducting a functional magnetic resonance imaging (fMRI) experiment with participants diagnosed with CUD (n = 13) and matched healthy controls (HC; n = 17). CUD participants showed a positive correlation between bilateral DLPFC-to-putamen effective connectivity and treatment effectiveness score. These preliminary results support further investigation of prefrontal-striatal interactions in response to treatment in CUD. Copyright © 2020 Elsevier B.V. All rights reserved.


    A D Snyder, E Zuniga, L Ma, J L Steinberg, K Woisard, P A Narayana, S Lane, J Schmitz, F G Moeller. Examination of preliminary behavioral and effective connectivity findings from treatment response to citalopram in cocaine use disorder: A dynamic causal modeling study. Psychiatry research. Neuroimaging. 2020 Sep 30;303:111127

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    PMID: 32593950

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