Correlation Engine 2.0
Clear Search sequence regions

  • cancer (1)
  • cell death (1)
  • hepatoma (1)
  • humans (1)
  • hypericin (4)
  • lung tumor (2)
  • mice (1)
  • patients (1)
  • Sizes of these terms reflect their relevance to your search.

    Efficacy of photodynamic therapy (PDT) with hypericin was compared using two cell lines in monolayer culture. Photokilling was substantially impaired in the A549 (human-derived lung tumor) when compared with the 1c1c7 murine hepatoma. The efficacy of PDT with regard to photokilling was correlated with the steady-state intracellular hypericin concentration. There was otherwise no difference in subcellular targets or the pathway to cell death: paraptosis. In a prior study involving cell lines derived from patients with head and neck cancer, differences in response to PDT had shown no correlation with photosensitizer uptake. © 2020 American Society for Photobiology.


    David Kessel. Hypericin Accumulation as a Determinant of PDT Efficacy. Photochemistry and photobiology. 2020 Sep;96(5):1144-1147

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 32599667

    View Full Text