An Analysis of ESR2 and CYP19A1 Gene Expression Levels in Women With Endometriosis.

Tomasz Szaflik, Beata Smolarz, Beata Mroczkowska, Bartosz Kulig, Malwina Soja, Hanna Romanowicz, Magdalena BryŚ, Ewa Forma, Krzysztof SzyŁŁo

In vivo (Athens, Greece) 2020 Jul-Aug

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The analysis of oestrogen receptor (ESR2) and cytochrome P450 family 19 subfamily A member (CYP19A1) gene expression in the context of the risk for endometriosis development. Tissue specimens, collected from patients with endometriosis (n=100) and from control patients (n=100) embedded into paraffin blocks, provided the material for genetic studies, oriented towards the expression of ESR2 and CYP19A1 genes. The gene expression was assessed by the reverse transcription-polymerase chain reaction technique. Higher expression levels of ESR2 gene were demonstrated in the patients with endometriosis in comparison with the healthy controls. The expression intensity of CYP19A1 gene was associated with endometriosis, manifested as abdominal wall nodules. A relationship was observed between CYP19A1 gene expression and the Revised American Society for Reproductive Medicine classification in the group with ovarian endometrioid cysts, as well as in the group with peritoneal endometriosis. This study suggests the significant role of ESR2 and CYP19A1 gene expression in the pathogenesis of endometriosis. Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Citation

Tomasz Szaflik, Beata Smolarz, Beata Mroczkowska, Bartosz Kulig, Malwina Soja, Hanna Romanowicz, Magdalena BryŚ, Ewa Forma, Krzysztof SzyŁŁo. An Analysis of ESR2 and CYP19A1 Gene Expression Levels in Women With Endometriosis. In vivo (Athens, Greece). 2020 Jul-Aug;34(4):1765-1771