Benzofuran derivatives with nerve growth factor-potentiating activity from Phellinus ribis.

Three new benzofuran derivatives, namely ribisin E (1) ribisin F (2) along with ribisin G (3) were isolated from the MeOH extract of the fruiting bodies of Phellinus ribis. Their structures were elucidated based on the NMR analysis. Furthermore, the absolute configuration of ribisin E (1) and ribisin G (3) were deduced by the CD calculations, and the absolute configuration of ribisin F (2) was determined by comparing its CD spectrum and specific rotation with the data of known analogues. All compounds (1-3) exhibited the activity of promoting neurite outgrowth in nerve growth factor (NGF)-ediated PC 12 cell at concentrations ranging from 1 to 30 μM.

Citation

Mei-Yue Dong, Yan Zhang, Hai-Qiang Jiang, Wen-Jing Ren, Ling-Chuan Xu, Yong-Qing Zhang, Yu-Hong Liu. Benzofuran derivatives with nerve growth factor-potentiating activity from Phellinus ribis. Natural product research. 2021 Dec;35(23):5145-5152

Mesh Tags

Substances

PMID: 32608259

search → result