CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.

Adipose tissues dynamically remodel their cellular composition in response to external cues by stimulating beige adipocyte biogenesis; however, the developmental origin and pathways regulating this process remain insufficiently understood owing to adipose tissue heterogeneity. Here, we employed single-cell RNA-seq and identified a unique subset of adipocyte progenitor cells (APCs) that possessed the cell-intrinsic plasticity to give rise to beige fat. This beige APC population is proliferative and marked by cell-surface proteins, including PDGFRα, Sca1, and CD81. Notably, CD81 is not only a beige APC marker but also required for de novo beige fat biogenesis following cold exposure. CD81 forms a complex with αV/β1 and αV/β5 integrins and mediates the activation of integrin-FAK signaling in response to irisin. Importantly, CD81 loss causes diet-induced obesity, insulin resistance, and adipose tissue inflammation. These results suggest that CD81 functions as a key sensor of external inputs and controls beige APC proliferation and whole-body energy homeostasis. Copyright © 2020 Elsevier Inc. All rights reserved.

Citation

Yasuo Oguri, Kosaku Shinoda, Hyeonwoo Kim, Diana L Alba, W Reid Bolus, Qiang Wang, Zachary Brown, Rachana N Pradhan, Kazuki Tajima, Takeshi Yoneshiro, Kenji Ikeda, Yong Chen, Rachel T Cheang, Kazuyuki Tsujino, Caroline R Kim, Vanille Juliette Greiner, Ritwik Datta, Christopher D Yang, Kamran Atabai, Michael T McManus, Suneil K Koliwad, Bruce M Spiegelman, Shingo Kajimura. CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling. Cell. 2020 Aug 06;182(3):563-577.e20

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PMID: 32615086

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