Flipping the Switch from Inflammation to Cell Death.

Multiple research groups have demonstrated that caspase-8 (CASP8)-mediated gasdermin D (GSDMD) cleavage drives pyroptotic cell death. Here, we discuss a novel role for the enzymatically inactive homolog of CASP8, the long isoform of cellular FLICE-like inhibitory protein (cFLIPL), in the regulation of this process. Specifically, cFLIP-deficiency provides a model in which to study the mechanisms regulating CASP8-mediated activation of cell death and inflammatory signaling. Copyright © 2020 Elsevier Ltd. All rights reserved.

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Hayley I Muendlein, Alexander Poltorak. Flipping the Switch from Inflammation to Cell Death. Trends in immunology. 2020 Aug;41(8):648-651

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PMID: 32622855

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