Impact of HLA polymorphisms among cadaveric donors on kidney graft allocation.

Zorana Grubic, Marija Burek Kamenaric, Julijana Kljajic, Katarina Stingl Jankovic, Marija Maskalan, Renata Zunec

Transplant immunology 2020 Oct

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This study provides data on HLA-A, -B, and -DRB1 frequencies among 861 end-stage renal disease (ESRD) patients from Croatia and estimates the benefit of the kidney exchange program by comparing HLA distribution and assessing HLA mismatches (MMs) within a group of ESRD patients who received kidney grafts from 707 cadaveric donors (422 from Croatia and 285 from Eurotransplant). Patients positive for HLA-B*07, -B*08, or -B*44 genes more often received a kidney from ET donors, while HLA-DRB1*11 and -DRB1*16 positive patients more frequently received a kidney from CRO donors. ABDR MM 000 was more frequently present in the case of transplantation from ET donors, while MM 222 was significantly more frequent when the donor was from Croatia. Sensitized patients received kidney more frequently from ET donors (P < .0001). A large pool of organ donors with different HLA gene distributions allows for a higher probability of transplantation from HLA highly matched donor. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Zorana Grubic, Marija Burek Kamenaric, Julijana Kljajic, Katarina Stingl Jankovic, Marija Maskalan, Renata Zunec. Impact of HLA polymorphisms among cadaveric donors on kidney graft allocation. Transplant immunology. 2020 Oct;62:101318