Dizygotic twins with prolonged jaundice and microcytic, hypochromic, hemolytic anemia with pyropoikilocytosis.

Timothy M Bahr, Michell Lozano-Chinga, Archana M Agarwal, Jessica A Meznarich, Erick Gerday, Jennifer L Smoot, Ann Taylor, Robert D Christensen

Blood cells, molecules & diseases 2020 Nov

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Dizygotic twin males, born at 34 weeks gestation, had prolonged jaundice, microcytic, hypochromic anemia, FABarts hemoglobin, elevated end-tidal CO, and blood films consistent with hereditary pyropoikilocytosis. DNA sequencing revealed both had a heterozygous alpha spectrin (SPTA1) mutation (c.460_462dup) inherited from their asymptomatic mother, plus a 3-base pair duplication in alpha globin (HBA2) (c.364_366dupGTG) inherited from their asymptomatic father. Copyright © 2020 Elsevier Inc. All rights reserved.

Citation

Timothy M Bahr, Michell Lozano-Chinga, Archana M Agarwal, Jessica A Meznarich, Erick Gerday, Jennifer L Smoot, Ann Taylor, Robert D Christensen. Dizygotic twins with prolonged jaundice and microcytic, hypochromic, hemolytic anemia with pyropoikilocytosis. Blood cells, molecules & diseases. 2020 Nov;85:102462