The Role of Glypicans in Cancer Progression and Therapy.

Glypicans are a family of heparan sulfate proteoglycans that are attached to the cell membrane via a glycosylphosphatidylinositol anchor. Glypicans interact with multiple ligands, including morphogens, growth factors, chemokines, ligands, receptors, and components of the extracellular matrix through their heparan sulfate chains and core protein. Therefore, glypicans can function as coreceptors to regulate cell proliferation, cell motility, and morphogenesis. In addition, some glypicans are abnormally expressed in cancers, possibly involved in tumorigenesis, and have the potential to be cancer-specific biomarkers. Here, we provide a brief review focusing on the expression of glypicans in various cancers and their potential to be targets for cancer therapy.

Citation

Nan Li, Madeline R Spetz, Mitchell Ho. The Role of Glypicans in Cancer Progression and Therapy. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2020 Dec;68(12):841-862

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PMID: 32623934

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