Endothelin-1 in the pathophysiology of obesity and insulin resistance.

Haley N Jenkins, Osvaldo Rivera-Gonzalez, Yann Gibert, Joshua S Speed

Obesity reviews : an official journal of the International Association for the Study of Obesity 2020 Dec

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The association between plasma endothelin-1 (ET-1) and obesity has been documented for decades, yet the contribution of ET-1 to risk factors associated with obesity is not fully understood. In 1994, one of first papers to document this association also noted a positive correlation between plasma insulin and ET-1, suggesting a potential contribution of ET-1 to the development of insulin resistance. Both endogenous receptors for ET-1, ETA and ETB are present in all insulin-sensitive tissues including adipose, liver and muscle, and ET-1 actions within these tissues suggest that ET-1 may be playing a role in the pathogenesis of insulin resistance. Further, antagonists for ET-1 receptors are clinically approved making these sites attractive therapeutic targets. This review focuses on known mechanisms through which ET-1 affects plasma lipid profiles and insulin signalling in these metabolically important tissues and also identifies gaps in our understanding of ET-1 in obesity-related pathophysiology. © 2020 World Obesity Federation.

Citation

Haley N Jenkins, Osvaldo Rivera-Gonzalez, Yann Gibert, Joshua S Speed. Endothelin-1 in the pathophysiology of obesity and insulin resistance. Obesity reviews : an official journal of the International Association for the Study of Obesity. 2020 Dec;21(12):e13086