Magnetic Solid-Phase Extraction Based on Poly 4-Vinyl Pyridine for HPLC-FLD Analysis of Naproxen in Urine Samples.

Karen A Escamilla-Lara, Ana C Heredia, Araceli Peña-Alvarez, Israel S Ibarra, Enrique Barrado, Jose A Rodriguez

Molecules (Basel, Switzerland) 2020 Jun 25

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A magnetic solid phase extraction technique followed by liquid chromatography with a fluorescence detector for naproxen analysis in human urine samples was developed. The method includes the extraction of naproxen with a magnetic solid synthetized with magnetite and poly 4-vinylpriridine, followed by the magnetic separation of the solid phase and desorption of the analyte with methanol. Under optimal conditions, the linear range of the calibration curve was 0.05-0.60 μg L-1, with a limit of detection of 0.02 μg L-1. In all cases values of repeatability were lower than 5.0% with recoveries of 99.4 ± 1.3%. Precision and accuracy values are adequate for naproxen (Npx) analysis in urine samples.

Citation

Karen A Escamilla-Lara, Ana C Heredia, Araceli Peña-Alvarez, Israel S Ibarra, Enrique Barrado, Jose A Rodriguez. Magnetic Solid-Phase Extraction Based on Poly 4-Vinyl Pyridine for HPLC-FLD Analysis of Naproxen in Urine Samples. Molecules (Basel, Switzerland). 2020 Jun 25;25(12)