Rad51 filament dynamics and its antagonistic modulators.

Alexander Carver, Xiaodong Zhang

Seminars in cell & developmental biology 2021 May

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Rad51 recombinase is the central player in homologous recombination, the faithful repair pathway for double-strand breaks and key event during meiosis. Rad51 forms nucleoprotein filaments on single-stranded DNA, exposed by a double-strand break. These filaments are responsible for homology search and strand invasion, which lead to homology-directed repair. Due to its central roles in DNA repair and genome stability, Rad51 is modulated by multiple factors and post-translational modifications. In this review, we summarize our current understanding of the dynamics of Rad51 filaments, the roles of other factors and their modes of action in modulating key stages of Rad51 filaments: formation, stability and disassembly. Copyright © 2020 Elsevier Ltd. All rights reserved.

Citation

Alexander Carver, Xiaodong Zhang. Rad51 filament dynamics and its antagonistic modulators. Seminars in cell & developmental biology. 2021 May;113:3-13