Immunological and anticancer activities of seleno-ovalbumin (Se-OVA) on H22-bearing mice.

Ovalbumin is the main protein component of egg white. Selenium is one of the essential trace elements. In our research, ovalbumin was modified into seleno-ovalbumin. After seleno-modification, the FTIR spectrum of seleno-ovalbumin appeared two new absorption peaks which belonged to the characteristic absorption peaks of Se-O and SeO. Seleno-ovalbumin could reduce the damage of cancer to immune organs, improve the proliferation capacities of T and B lymphocytes, enhance the NK cells cytotoxicity and increase the phagocytic activity of peritoneal macrophages of H22-bearing mice. Besides, Se-OVA could block the cell cycle of solid tumors cells in G0/G1 phase and accelerate the apoptosis of solid tumors cells through mitochondrial pathway. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Naxin Sun, Anguo Teng, Yana Zhao, Huiping Liu, Jianqiu Tu, Qi Jia, Qing Wang. Immunological and anticancer activities of seleno-ovalbumin (Se-OVA) on H22-bearing mice. International journal of biological macromolecules. 2020 Nov 15;163:657-665

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PMID: 32634513

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