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Antimicrobial peptides (AMPs) are molecular factors in innate immunity and are believed to play a key role in invertebrate host defence. We identified theromacin (TM) from an Asian polychaeta, Perinereis linea, using de novo RNA-seq analysis. TM, a typical AMP of invertebrates, is a cysteine-rich AMP with five disulfide bonds consisting of ten cysteine residues. In gene expression analysis, TM genes were constantly upregulated after lipopolysaccharide (LPS) stimulation. In contrast, after peptidoglycan (PGN) stimulation, it was upregulated initially and downregulated after 12 h. We synthesized a peptide based on the macin AMP in the TM amino acid sequence. The synthetic peptide showed antibacterial activity against some Gram-positive and Gram-negative bacteria. Therefore, the AMPs of P. linea might have broad roles in host defence and exhibit different degrees of activity. Copyright © 2020 Elsevier Ltd. All rights reserved.


Min-Soo Joo, Kwang-Min Choi, Dong-Hee Cho, Hye-Sung Choi, Eun Young Min, Hyun-Ja Han, Mi Young Cho, Jin-Sol Bae, Chan-Il Park. The molecular characterization, expression analysis and antimicrobial activity of theromacin from Asian polychaeta (Perinereis linea). Developmental and comparative immunology. 2020 Nov;112:103773

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PMID: 32634521

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