SARS-CoV2 envelope protein: non-synonymous mutations and its consequences.

In the NCBI database, as on June 6, 2020, total number of available complete genome sequences of SARS-CoV2 across the world is 3617. The envelope (E) protein of SARS-CoV2 possesses several non-synonymous mutations over the transmembrane and C-terminus domains in 15 (0.414%) genomes among 3617 SARS-CoV2 genomes, analyzed. More precisely, 10(0.386%) out of 2588 genomes from the USA, 3(0.806%) from Asia, 1 (0.348%) from Europe and 1 (0.274%) from Oceania contained the missense mutations over the E-protein of SARS-CoV2 genomes. The C-terminus motif DLLV has been to DFLV and YLLV in the proteins from QJR88103 (Australia: Victoria) and QKI36831 (China: Guangzhou) respectively, which might affect the binding of this motif with the host protein PALS1. Copyright © 2020 Elsevier Inc. All rights reserved.

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Sk Sarif Hassan, Pabitra Pal Choudhury, Bidyut Roy. SARS-CoV2 envelope protein: non-synonymous mutations and its consequences. Genomics. 2020 Nov;112(6):3890-3892

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PMID: 32640274

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