Correlation Engine 2.0
Clear Search sequence regions

  • dendrite (3)
  • dendron (4)
  • female (2)
  • GnRH (10)
  • LH (7)
  • mice (2)
  • soma (3)
  • Sizes of these terms reflect their relevance to your search.

    The gonadotropin-releasing hormone (GnRH) neurons exhibit pulse and surge modes of activity to control fertility. They also exhibit an unusual bipolar morphology comprised of a classical soma-proximal dendritic zone and an elongated secretory process that can operate as both a dendrite and an axon, termed a 'dendron'. We show using expansion microscopy that the highest density of synaptic inputs to a GnRH neuron exists at its distal dendron. In vivo, selective chemogenetic inhibition of the GnRH neuron distal dendron abolishes the luteinizing hormone (LH) surge and markedly dampens LH pulses. In contrast, inhibitory chemogenetic and optogenetic strategies targeting the GnRH neuron soma-proximal dendritic zone abolish the LH surge but have no effect upon LH pulsatility. These observations indicate that electrical activity at the soma-proximal dendrites of the GnRH neuron is only essential for the LH surge while the distal dendron represents an autonomous zone where synaptic integration drives pulsatile GnRH secretion. © 2020, Wang et al.


    Li Wang, Wenya Guo, Xi Shen, Shel Yeo, Hui Long, Zhexuan Wang, Qifeng Lyu, Allan E Herbison, Yanping Kuang. Different dendritic domains of the GnRH neuron underlie the pulse and surge modes of GnRH secretion in female mice. eLife. 2020 Jul 09;9

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 32644040

    View Full Text