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Oral cladribine is a highly effective pulsed selective immune reconstitution therapy licensed for relapsing multiple sclerosis. A full treatment course comprises two treatment cycles given with 1 year of intermission. Further dosing is not routinely recommended in years 3 and 4. The long-term management of patients treated with oral cladribine has not been fully defined on the basis of clinical studies as of yet. The authors provide their expert opinion on this. Based on available evidence and experience from routine clinical use, the authors suggest a structured approach to the long-term management of patients treated with cladribine tablets according to their responder type, i. e. the degree and timing of disease activity, if any, after treatment initiation. Informed treatment decisions require structured patient monitoring by established clinical and imaging parameters. In patients with relevant disease activity in year 3 or 4 and beyond, the use of additional cycle(s) of oral cladribine might become an option. For patients requiring a treatment switch, the choice of therapies primarily includes moderately to highly effective MS drugs.


Sven G Meuth, Antonios Bayas, Boris Kallmann, Christoph Kleinschnitz, Ralf Linker, Peter Rieckmann, Mathias Mäurer. Long-term management of multiple sclerosis patients treated with cladribine tablets: an expert opinion. Expert opinion on pharmacotherapy. 2020 Nov;21(16):1965-1969

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PMID: 32658554

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