Opinions of African American adults about the use of apolipoprotein L1 (ApoL1) genetic testing in living kidney donation and transplantation.

Margaret Berrigan, Jasmine Austrie, Aaron Fleishman, Kenneth P Tercyak, Martin R Pollak, Martha Pavlakis, Vinayak Rohan, Prabhakar K Baliga, Liise K Kayler, Thomas H Feeley, James R Rodrigue

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2021 Mar

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Apolipoprotein L1 (ApoL1) predictive genetic testing for kidney disease, and its emerging role in transplantation, remains controversial as it may exacerbate underlying disparities among African Americans (AAs) at increased risk. We conducted an online simulation among AAs (N = 585) about interest in ApoL1 testing and its cofactors, under 2 scenarios: as a potential living donor (PLD), and as a patient awaiting transplantation. Most respondents (61%) expressed high interest in genetic testing as a PLD: age ≥35 years (adjusted odds ratio [aOR], 1.75; 95% confidence interval [CI], 1.18, 2.60, P = .01), AA identity (aOR, 1.67; 95% CI, 1.02, 2.72, P = .04), perceived kidney disease risk following donation (aOR, 1.68; 95% CI, 1.03, 2.73, P = .03), interest in genetics (aOR, 2.89; 95% CI, 1.95, 4.29, P = .001), and genetics self-efficacy (aOR, 2.38; 95% CI, 1.54, 3.67, P = .001) were positively associated with ApoL1 test interest. If awaiting transplantation, most (89%) believed that ApoL1 testing should be done on AA deceased donors, and older age (aOR, 1.85; 95% CI, 1.03, 3.32, P = .04) and greater interest in genetics (aOR, 2.61; 95% CI, 1.41, 4.81, P = .002) were associated with interest in testing deceased donors. Findings highlight strong support for ApoL1 testing in AAs and the need to examine such opinions among PLDs and transplant patients to enhance patient education efforts. © 2020 The American Society of Transplantation and the American Society of Transplant Surgeons.

Citation

Margaret Berrigan, Jasmine Austrie, Aaron Fleishman, Kenneth P Tercyak, Martin R Pollak, Martha Pavlakis, Vinayak Rohan, Prabhakar K Baliga, Liise K Kayler, Thomas H Feeley, James R Rodrigue. Opinions of African American adults about the use of apolipoprotein L1 (ApoL1) genetic testing in living kidney donation and transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2021 Mar;21(3):1197-1205