Complications of metabolic acidosis and alkalinizing therapy in chronic kidney disease patients: a clinician-directed organ-specific primer.

Sidar Copur, Alan A Sag, Baris Afsar, Patrick Rossignol, Adrian Covic, Mehmet Kanbay

International urology and nephrology 2020 Dec

filter terms:

Chronic kidney disease is prevalent, affecting more than one in ten adults. In this population, metabolic acidosis is considered a key underlying pathophysiological feature, tying together bone mineral disorders, sarcopenia, insulin resistance, vascular calcification, pro-inflammatory and pro-thrombotic states. This review aims to address the paucity of literature on alkalinizing agents, a promising treatment option that has known adverse effects.

Citation

Sidar Copur, Alan A Sag, Baris Afsar, Patrick Rossignol, Adrian Covic, Mehmet Kanbay. Complications of metabolic acidosis and alkalinizing therapy in chronic kidney disease patients: a clinician-directed organ-specific primer. International urology and nephrology. 2020 Dec;52(12):2311-2320