Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland.

A T Coste, A Kritikos, J Li, N Khanna, D Goldenberger, C Garzoni, C Zehnder, K Boggian, D Neofytos, A Riat, D Bachmann, D Sanglard, F Lamoth, Fungal Infection Network of Switzerland (FUNGINOS)

Infection 2020 Oct

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Echinocandins represent the first-line therapy of candidemia. Echinocandin resistance among Candida spp. is mainly due to acquired FKS mutations. In this study, we report the emergence of FKS-mutant Candida albicans/glabrata in Switzerland and provide the microbiological and clinical characteristics of 9 candidemic episodes. All patients were previously exposed to echinocandins (median 26 days; range 15-77). Five patients received initial echinocandin therapy with persistent candidemia in 4 of them. Overall mortality was 33%.

Citation

A T Coste, A Kritikos, J Li, N Khanna, D Goldenberger, C Garzoni, C Zehnder, K Boggian, D Neofytos, A Riat, D Bachmann, D Sanglard, F Lamoth, Fungal Infection Network of Switzerland (FUNGINOS). Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland. Infection. 2020 Oct;48(5):761-766