Engineering immunogenic cell death with nanosized drug delivery systems improving cancer immunotherapy.

Wenlu Yan, Tianqun Lang, Xianrong Qi, Yaping Li

Current opinion in biotechnology 2020 Dec

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Many anti-cancer therapies can induce or enhance the immunogenic cell death (ICD), a process that releases damage-associated molecular patterns (DAMPs) to prime antigen processing and presentation necessary for successful cancer immunotherapy. However, the clinical potential of these therapies, especially the chemotherapy, is limited by serious systemic side effects, because of their non-specific accumulation out of the tumors. Nanosized drug delivery systems (NDDSs) can improve the specificity of anti-cancer therapies, which enhance ICD in the tumor while alleviating toxicities. In this review, we summarize recent progress of ICD-inducing NDDSs with a focus on their enhanced safety and efficacy for cancer immunotherapy. Copyright © 2020 Elsevier Ltd. All rights reserved.

Citation

Wenlu Yan, Tianqun Lang, Xianrong Qi, Yaping Li. Engineering immunogenic cell death with nanosized drug delivery systems improving cancer immunotherapy. Current opinion in biotechnology. 2020 Dec;66:36-43