N-alkylated linear heptamethine polyenes as potent non-azole leads against Candida albicans fungal infections.

Clare L Lawrence, Adeyi Okoh Okoh, Vinod Vishwapathi, Sean T McKenna, Megan E Critchley, Robert B Smith

Bioorganic chemistry 2020 Sep

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In this study, eighteen heptamethine dyes were synthesised and their antifungal activities were evaluated against three clinically relevant yeast species.. The eighteen dyes were placed within classes based on their core subunit i.e. 2,3,3-trimethylindolenine (5a-f), 1,1,2-trimethyl-1H-benzo[e]indole (6a-f), or 2-methylbenzothiazole (7a-f). The results presented herein imply that the three families of cyanine dyes, in particular compounds 5a-f, show high potential as selective scaffolds to treat C. albicans infections. This opens up the opportunity for further optimisation and investigation of this class compounds for potential antifungal treatment. Copyright © 2020 Elsevier Inc. All rights reserved.

Citation

Clare L Lawrence, Adeyi Okoh Okoh, Vinod Vishwapathi, Sean T McKenna, Megan E Critchley, Robert B Smith. N-alkylated linear heptamethine polyenes as potent non-azole leads against Candida albicans fungal infections. Bioorganic chemistry. 2020 Sep;102:104070