Children with type 1 diabetes have elevated high-sensitivity C-reactive protein compared with a control group.

Pilar Pérez-Segura, Olaya de Dios, Leticia Herrero, Claudia Vales-Villamarín, Isabel Aragón-Gómez, Teresa Gavela-Pérez, Carmen Garcés, Leandro Soriano-Guillén

BMJ open diabetes research & care 2020 Jul

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Our objective was to compare high-sensitivity C-reactive protein (hsCRP) levels in children with type 1 diabetes, healthy controls, and children with obesity. Additionally, we aimed to analyze the association between hsCRP levels and glycemic control measured by glycohemoglobin A (HbA1c) and anthropometric and biochemical variables. We conducted a non-randomized descriptive study of children with type 1 diabetes matched for sex and age with a control group and group with obesity. We recorded anthropometric parameters and studied variables related to diabetes, blood pressure, lipid profile, and HbA1c. hsCRP was measured by ELISA. We included 49 children with type 1 diabetes, 46 controls, and 40 children with obesity. hsCRP levels were significantly higher in the group with type 1 diabetes compared with controls and nearly significantly lower than in the group comprising children with obesity. We found no correlation between hsCRP and HbA1c and characteristics of type 1 diabetes with the exception of albumin to creatinine ratio. Statistically significant association was found between hsCRP and body mass index (BMI) and waist circumference Z-score. The higher hsCRP levels observed in children with type 1 diabetes compared with a control group with a similar BMI suggest a basal inflammatory state that could increase cardiovascular risk. The main factors related to hsCRP are BMI and waist circumference, so obesity prevention should be a priority when performing follow-up in children with type 1 diabetes. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Citation

Pilar Pérez-Segura, Olaya de Dios, Leticia Herrero, Claudia Vales-Villamarín, Isabel Aragón-Gómez, Teresa Gavela-Pérez, Carmen Garcés, Leandro Soriano-Guillén. Children with type 1 diabetes have elevated high-sensitivity C-reactive protein compared with a control group. BMJ open diabetes research & care. 2020 Jul;8(1)