Responsive fluorinated nanoemulsions for 19F magnetic resonance detection of cellular hypoxia.

Rahul T Kadakia, Da Xie, Hongyu Guo, Bailey Bouley, Meng Yu, Emily L Que

Dalton transactions (Cambridge, England : 2003) 2020 Nov 25

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We report two highly fluorinated Cu-based imaging agents, CuL1 and CuL2, for detecting cellular hypoxia as nanoemulsion formulations. Both complexes retained their initial quenched 19F MR signals due to paramagnetic Cu2+; however, both complexes displayed a large signal increase when the complex was reduced. DLS studies showed that the CuL1 nanoemulsion (NECuL1) had a hydrodiameter of approximately 100 nm and that it was stable for four weeks post-preparation. Hypoxic cells incubated with NECuL1 showed that 40% of the Cu2+ taken up was reduced in low oxygen environments.

Citation

Rahul T Kadakia, Da Xie, Hongyu Guo, Bailey Bouley, Meng Yu, Emily L Que. Responsive fluorinated nanoemulsions for 19F magnetic resonance detection of cellular hypoxia. Dalton transactions (Cambridge, England : 2003). 2020 Nov 25;49(45):16419-16424