Investigating the clinical, hematological and cytogenetic profile of endoreduplicated hypodiploids in BCP-ALL.

Ploidy, besides known translocations in lymphoblasts, is a strong predictor of prognosis in B- cell progenitor acute lymphoblastic leukemia (BCP-ALL). While hyperdiploidy with >50 chromosomes shows a favourable outcome, hypodiploidy with <45 chromosomes have a dismal clinical outcome. However, there exists a small subset where both the hypodiploid and hyperdiploid clones are apparent either by cytogenetics or flow cytometry and are defined partially masked hypodiploids or mosaics based on the percentage of clonal population. These patients are essentially hypodiploids, and show the hyperdiploid clone as a consequence of endoreduplication of the primary hypodiploid clone- A phenomenon of successive replication of genome without mitosis (cytokinesis) resulting in increased ploidy. In the current study, we present the complete clinical, hematological and cytogenetic profile of 11 such newly diagnosed mosaics or partially masked hypodiploid BCP-ALL cases. Copyright © 2020 Elsevier Inc. All rights reserved.

Citation

Dhanlaxmi Shetty, Pratibha Kadam Amare, Purvi Mohanty, Elizabeth Talker, Kruti Chaubal, Hemani Jain, Prashant Tembhare, Nikhil Patkar, Anumeha Chaturvedi, P G Subramanian, Nirmalya Moulik, Chetan Dhamne, Hasmukh Jain, Bhausaheb Bagal, Gaurav Narula, Manju Sengar, Navin Khattry, Shripad Banavali. Investigating the clinical, hematological and cytogenetic profile of endoreduplicated hypodiploids in BCP-ALL. Blood cells, molecules & diseases. 2020 Nov;85:102465

Mesh Tags

PMID: 32693366

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