Exposure to Moderate Glycosuria Induces Virulence of Group B Streptococcus.

Preeti P John, Brady C Baker, Santosh Paudel, Lauren Nassour, Hayden Cagle, Ritwij Kulkarni

The Journal of infectious diseases 2021 Mar 03

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To explore whether glycosuria induces virulence of uropathogens, in turn facilitating urinary tract infection (UTI), we exposed group B Streptococcus (GBS) strain 10/84 to human urine plain or with 300 mg/dL glucose (mimicking moderate glycosuria). Exposure to moderate glycosuria significantly augmented bacterial growth, kidney bacterial burden in a mouse model of ascending UTI, and virulence characteristics and expression of corresponding genes. Exposure to glycosuria increased GBS adherence to human bladder epithelial cell line and expression of corresponding PI2a fimbrial gene, antimicrobial peptide LL-37 resistance and bacterial surface charge modulating dltA, and GBS hemolytic ability and expression of genes encoding pore-forming toxins. © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Citation

Preeti P John, Brady C Baker, Santosh Paudel, Lauren Nassour, Hayden Cagle, Ritwij Kulkarni. Exposure to Moderate Glycosuria Induces Virulence of Group B Streptococcus. The Journal of infectious diseases. 2021 Mar 03;223(5):843-847