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PLTP plays an important role in lipoprotein metabolism and cardiovascular disease development in humans; however, the mechanisms are still not completely understood. In mouse models, PLTP deficiency reduces cardiovascular disease, while its overexpression induces it. Therefore, we used mouse models to investigate the involved mechanisms. In this chapter, the recent main progresses in the field of PLTP research are summarized, and our focus is on the relationship between PLTP and lipoprotein metabolism, as well as PLTP and cardiovascular diseases.


Xian-Cheng Jiang. Impact of Phospholipid Transfer Protein in Lipid Metabolism and Cardiovascular Diseases. Advances in experimental medicine and biology. 2020;1276:1-13

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PMID: 32705590

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