Proteomics in thyroid cancer and other thyroid-related diseases: A review of the literature.

Yasemin Ucal, Aysel Ozpinar

Biochimica et biophysica acta. Proteins and proteomics 2020 Nov

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Misdiagnosis, over-diagnosis, or inappropriate treatment strategies are frequently seen in thyroid disease management. Currently, there is an urgent interest to identify biomarkers for specific disease states in the thyroid gland. Proteomics-based approaches have been widely used for the discovery of potential biomarkers in thyroid research. Specifically, proteomic techniques have been used to better understand thyroid tumors of different origin and classification. Besides, there is remarkable thyroid proteomics research in thyroid-related diseases, including thyroid orbitopathy. In this review, we aim to describe proteomic studies and how the results obtained from thyroid cancer, up to now, as well as those from, other thyroid-related diseases pose challenges, which might be solved via high-resolution protein analysis. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Yasemin Ucal, Aysel Ozpinar. Proteomics in thyroid cancer and other thyroid-related diseases: A review of the literature. Biochimica et biophysica acta. Proteins and proteomics. 2020 Nov;1868(11):140510