The controversial role of IL-6 in adipose tissue on obesity-induced dysregulation of glucose metabolism.

Interleukin (IL)-6 is a pleotropic cytokine with various physiological and pathophysiological functions in different cells and tissues. In cells residing within white adipose tissue, several, and sometimes conflicting, IL-6 actions have been described in the development of obesity-associated derangements of glucose metabolism. Herein, we aim to summarize opposing findings and discuss recent evidence that IL-6 signaling in adipose tissue is regulated in a depot and cell-specific manner.

Citation

Stephan Wueest, Daniel Konrad. The controversial role of IL-6 in adipose tissue on obesity-induced dysregulation of glucose metabolism. American journal of physiology. Endocrinology and metabolism. 2020 Sep 01;319(3):E607-E613

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PMID: 32715746

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