Bioactive Metabolites from the Deep-Sea-Derived Fungus Diaporthe longicolla FS429.

Zhaoming Liu, Yuchan Chen, Saini Li, Qinglin Wang, Caiyun Hu, Hongxin Liu, Weimin Zhang

Marine drugs 2020 Jul 23

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The chemical investigation of a methanol extract of the deep-sea-derived fungus Diaporthe longicolla FS429 led to the isolation of two novel diterpenoids longidiacids A and B (1 and 2), two new polyketides (3 and 4), two new cytochalasin analogues longichalasins A and B (6 and 8) and three known analogues 5, 7, 9. Their structures were elucidated through comprehensive spectroscopic analysis, while the absolute configurations were established by the comparison of the experimental and quantum chemical calculated ECD spectra. The structure of compound 7 was confirmed through X-ray diffraction for the first time. In the bioassays compound 8 exhibited antiproliferative effects against SF-268, with an IC50 value of 16.44 μM. Moreover, compounds 1 and 8 were detected to inhibit 35.4% and 53.5% of enzyme activity of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) at a concentration of 50 μM.

Citation

Zhaoming Liu, Yuchan Chen, Saini Li, Qinglin Wang, Caiyun Hu, Hongxin Liu, Weimin Zhang. Bioactive Metabolites from the Deep-Sea-Derived Fungus Diaporthe longicolla FS429. Marine drugs. 2020 Jul 23;18(8)