Molecular Targets, Pathways, and Therapeutic Implications for Hepatocellular Carcinoma.

Jun Gong, Jeremy Chuang, May Cho, Kyra Toomey, Andrew Hendifar, Daneng Li

International journal of molecular sciences 2020 Jul 23

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Hepatocellular carcinoma (HCC) represents one of the leading causes of cancer mortality worldwide. While significant advances have been made for the treatment of advanced hepatocellular carcinoma in the past few years, the prognosis remains poor and effective biomarkers to guide selection of therapies remain noticeably absent. However, several targeted therapies have been approved in the past few years that have improved the outlook for this disease. In this review, we will highlight the recent therapies approved for the treatment of advanced HCC and discuss promising therapeutic options, targets, and pathways for drug development and consideration for future clinical trials.

Citation

Jun Gong, Jeremy Chuang, May Cho, Kyra Toomey, Andrew Hendifar, Daneng Li. Molecular Targets, Pathways, and Therapeutic Implications for Hepatocellular Carcinoma. International journal of molecular sciences. 2020 Jul 23;21(15)