The H-Y Antigen in Embryonic Stem Cells Causes Rejection in Syngeneic Female Recipients.

Stem cells and development 2020 Sep 15

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Pluripotent stem cells are promising candidates for cell-based regenerative therapies. To avoid rejection of transplanted cells, several approaches are being pursued to reduce immunogenicity of the cells or modulate the recipient's immune response. These include gene editing to reduce the antigenicity of cell products, immunosuppression of the host, or using major histocompatibility complex-matched cells from cell banks. In this context, we have investigated the antigenicity of H-Y antigens, a class of minor histocompatibility antigens encoded by the Y chromosome, to assess whether the gender of the donor affects the cell's antigenicity. In a murine transplant model, we show that the H-Y antigen in undifferentiated embryonic stem cells (ESCs), as well as ESC-derived endothelial cells, provokes T- and B cell responses in female recipients.

Citation

Xiaomeng Hu, Simon T Kueppers, Nigel G Kooreman, Alessia Gravina, Dong Wang, Grigol Tediashvili, Stephan Schlickeiser, Marco Frentsch, Christos Nikolaou, Andreas Thiel, Sivan Marcus, Sigrid Fuchs, Joachim Velden, Hermann Reichenspurner, Hans-Dieter Volk, Tobias Deuse, Sonja Schrepfer. The H-Y Antigen in Embryonic Stem Cells Causes Rejection in Syngeneic Female Recipients. Stem cells and development. 2020 Sep 15;29(18):1179-1189