ABCC8 mRNA expression is an independent prognostic factor for glioma and can predict chemosensitivity.

Kaijia Zhou, Yanwei Liu, Zheng Zhao, Yinyuan Wang, Lijie Huang, Ruichao Chai, Guanzhang Li, Tao Jiang

Scientific reports 2020 Jul 29

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Glioma is the most common primary intracranial tumor and is associated with very low survival rates. The development of reliable biomarkers can help to elucidate the molecular mechanisms involved in glioma development. Here the expression of ABCC8 mRNA, clinical characteristics, and survival information based on 1893 glioma samples from four independent databases were analyzed. The expression patterns of ABCC8 mRNA were compared by a Chi square test. The overall survival rate of gliomas was evaluated according to the expression level of ABCC8 mRNA. The prognostic value of this marker in gliomas was tested using Cox single factor and multi factor regression analyses. We found patients with low WHO grade, oligodendrocytoma, low molecular grade, IDH mutation, and 1p19q combined deletion had high ABCC8 mRNA expression. The patients with high expression of ABCC8 mRNA had longer survival. ABCC8 mRNA expression was a new independent prognostic index for glioma. Temozolomide chemotherapy was an independent index to prolong overall survival in high ABCC8 mRNA expression glioma patients, whereas in patients with low expression, there was no significant difference. So ABCC8 mRNA expression could be an independent prognostic indicator for glioma patients and could predict the sensitivity of glioma to temozolomide.

Citation

Kaijia Zhou, Yanwei Liu, Zheng Zhao, Yinyuan Wang, Lijie Huang, Ruichao Chai, Guanzhang Li, Tao Jiang. ABCC8 mRNA expression is an independent prognostic factor for glioma and can predict chemosensitivity. Scientific reports. 2020 Jul 29;10(1):12682