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Following A-to-I editing of double-stranded RNA (dsRNA) molecules, sequencing reactions interpret the edited inosine (I) as guanosine (G). For this reason, current methods to detect A-to-I editing sites work to align RNA sequences to their reference DNA sequence in order to reveal A-to-G mismatches. However, areas with heavily edited reads produce dense clusters of A-to-G mismatches that hinder alignment, and complicate correct identification of the sites. The presented approach employs prudent alignment and examination of excessive mismatch events, enabling high-accuracy detection of hyper-edited reads and sites.


Roni Cohen-Fultheim, Erez Y Levanon. Detection of A-to-I Hyper-edited RNA Sequences. Methods in molecular biology (Clifton, N.J.). 2021;2181:213-227

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PMID: 32729083

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