A new prenylated 3-benzoxepin derivative with anti-influenza A virus activity from Elsholtzia penduliflora.

Lu Zhang, Linyao Yang, Rong-Tao Li, Fei Yu, Jindong Zhong

Natural product research 2022 Feb

filter terms:

A new prenylated 3-benzoxepin derivative, elsholtzioxin (1), together with fifteen known compounds (2-16) were isolated from the whole parts of Elsholtzia penduliflora. Their structures were elucidated on the basis of various spectroscopic techniques and chemical evidences. The antiviral activities of these compounds were evaluated in vitro. The new compound (1) exhibited potential anti-influenza virus activity against strain A/WSN/33/2009 (H1N1) with inhibition rate of 47.19%. Compounds 2, 9 and 12 exhibited significant inhibitory activities with IC50 value of 26.16, 34.66 and 20.81 μM, respectively.

Citation

Lu Zhang, Linyao Yang, Rong-Tao Li, Fei Yu, Jindong Zhong. A new prenylated 3-benzoxepin derivative with anti-influenza A virus activity from Elsholtzia penduliflora. Natural product research. 2022 Feb;36(3):719-725